Research Insights

This section focuses on recent global studies and discoveries in the various fields of healthcare.

Functional Characterization of a Single Nucleotide Polymorphism Associated With Alzheimer’s Disease in a Hipsc-based Neuron Model

Neurodegenerative diseases encompass a group of debilitating conditions resulting from progressive nerve cell death Of these Alzheimers disease AD occurs most frequently but is currently incurable and has limited treatment success

Changes in Myocardial Blood Flow in a Canine Model of Left Sided Breast Cancer Radiotherapy

Leftsided breast cancer patients receiving adjuvant radiotherapy are at risk for coronary artery disease andor radiation mediated effects on the microvasculature

Peri-operative Pharmacokinetics of Cefazolin Prophylaxis During Valve Replacement Surgery

There is little prospective data to guide effective dosing for antibiotic prophylaxis during surgery requiring cardiopulmonary bypass CPB We aim to describe the effects of CPB on the population pharmacokinetics

Discovery of Neutralizing Sars-cov-2 Antibodies Enriched in a Unique Antigen Specific B Cell Cluster

Despite development of effective SARSCoV vaccines a subgroup of vaccine nonresponders depends on therapeutic antibodies or smallmolecule drugs in cases of severe disease

Clinical and Financial Outcomes of Hospitalizations for Cardiac Device Infection During the Covid-19 Pandemic in the Us

Cardiac device infection CDI can occur in up to of patients after device placement with mortality rates exceeding Although device removal is standard management

Noncanonical Rab9a Action Supports Retromer-mediated Endosomal Exit of Human Papillomavirus During Virus Entry

Rab GTPases play key roles in controlling intracellular vesicular transport GTPbound Rab proteins support vesicle trafficking Here we report that unlike cellular protein cargos retromermediated delivery of human papillomaviruses

Machine Learning Prediction of the Total Duration of Invasive and Non-invasive Ventilation During Icu Stay

Predicting the duration of ventilation in the ICU helps in assessing the risk of ventilatorinduced lung injury ensuring sufficient oxygenation and optimizing resource allocation

Impact of Covid-19 Pandemic on Pharmacologic Treatment of Patients Newly Diagnosed With Osteoporosis

This study determined whether initiation of pharmacologic treatment was delayed for newly diagnosed osteoporosis patients during the COVID pandemic

Short Dual Antiplatelet Therapy Duration After Percutaneous Coronary Intervention in High Bleeding Risk Patients: Systematic Review and Meta-analysis

Dual antiplatelet therapy DAPT following percutaneous coronary intervention PCI reduces major adverse cardiovascular events MACE and stent thrombosis However DAPT duration is a concern in high bleeding risk HBR patients

The ∆pv-aco2/∆ca-vo2 Ratio as a Predictor of Mortality in Patients With Severe Acute Respiratory Distress Syndrome Related to Covid-19

To evaluate the central venoustoarterial carbon dioxide difference combined with arterialtovenous oxygen content difference PvaCOCavO ratio as a predictor of mortality in patients with COVIDrelated severe acute respiratory distress syndrome ARDS