Mingjiang Luo, Zubing Mei, Siliang Tang, Jinshan Huang, Kun Yuan, Lingling Jiang, Zhifeng Tang,Keni Li, Mingxuan Su, Can Su, Yuxin Shi, Zihan Zhang, Jiang Chen, Yuan Zheng, Peng Bin, Zhengbing Yuan, Guosong Xu, Zhihong Xiao
Abstract
Sarcopenia is considered to be an important predictor of adverse outcomes following spinal surgery, but the specific relationship between the two is not clear. The purpose of this meta-analysis is to systematically review all relevant studies to evaluate the impact of sarcopenia on spinal surgery outcomes.
Introduction
Sarcopenia is a skeletal muscle disease that progresses with age and involves accelerated loss of muscle mass and function, including osteoporosis, fall proneness, weakness, dysfunction and death [1].
Methods
This study was conducted and reported in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analyses Protocol (PRISMA-P) guidelines [12] and the Assessing the Methodological Quality of Systematic Reviews (AMSTAR) guidelines [13]
Results
A preliminary search yielded 80,821 records and an additional 4 records from other sources. After removing duplicates (n = 2,488), 78,337 titles and abstracts were screened.
Discussion
This meta-analysis systematically reviewed data from 24 cohort studies and analyzed the relationship between sarcopenia and other postoperative outcomes of spinal surgery.
Conclusions
The current meta-analysis showed that patients with sarcopenia have increased risks of adverse events and mortality after spinal surgery.
Citation: Luo M, Mei Z, Tang S, Huang J, Yuan K, Jiang L, et al. (2024) The impact of sarcopenia on the incidence of postoperative outcomes following spine surgery: Systematic review and meta-analysis. PLoS ONE 19(8): e0302291. https://doi.org/10.1371/journal.pone.0302291
Editor: Hassan Zmerly, University of Bologna - Rimini Campus: Universita degli Studi di Bologna - Campus di Rimini, ITALY
Received: July 10, 2023; Accepted: April 1, 2024; Published: August 26, 2024
Copyright: © 2024 Luo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: All relevant data are within the manuscript and its Supporting Information files.
Funding: This study was financially supported by the Health and Family Planning Commission Program of Hunan Province in the form of a grant (202204074707) received by ZX. This study was also financially supported by the Health and Family Planning Commission Program of Wuhan City in the form of a grant (WX18C29) received by ZX. This study was also financially supported by Natural Science Foundation of Hunan Province in the form of a grant (2022JJ30516) received by ZX. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0302291#abstract0
