Gashaw Solela
Abstract
In patients with heart failure (HF), multiple electrolyte disorders are common, and recent studies have shown that chloride disorders play a significant role in the prognosis of HF. Data about the prevalence and prognostic role of hypochloremia in patients with acute HF (AHF).
Introduction
Heart failure (HF) has been defined as a global pandemic affecting 64.3 million people worldwide [1], and its prevalence is expected to rise due to improved survival with the availability of life-saving evidence-based treatments and the overall longer life expectancy of the general population [2].
Methods
This was a single-center retrospective analysis of AHF patients who had chloride determination on admission and were hospitalized in the medical wards or medical intensive care unit (ICU) of Y12HMC, Addis Ababa, Ethiopia, from July 1, 2022, to July 1, 2023.
Results
A total of 267 AHF patients who had a determination of chloride level on admission were found to be eligible and included in this study.
Discussions
This study, the first of its kind in sub-Saharan Africa, has assessed the prevalence, associated factors, and prognostic role of hypochloremia in patients with AHF at a single center in Ethiopia.
Conclusions
This study revealed a high prevalence of hypochloremia among patients with AHF. Low diastolic blood pressure and hyponatremia were significantly associated with the development of hypochloremia.
Citation: Solela G (2024) Prevalence and prognostic role of hypochloremia in patients with acute heart failure in Ethiopia: A single-center retrospective analysis. PLoS ONE 19(9): e0310251. https://doi.org/10.1371/journal.pone.0310251
Editor: Innocent Ijezie Chukwuonye, Federal Medical Centre Umuahia, NIGERIA
Received: May 22, 2024; Accepted: August 28, 2024; Published: September 12, 2024
Copyright: © 2024 Gashaw Solela. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: All relevant data are within the manuscript and its Supporting information files.
Funding: The author(s) received no specific funding for this work.
Competing interests: The author have declared that no competing interests exist.
List of abbreviations: AHF, Acute heart failure; BUN, Blood urea nitrogen; CKD, Chronic kidney disease; Cl, Chloride; DBP, Diastolic blood pressure; DM, Diabetes mellitus; HF, Heart Failure; Hgb, Hemoglobin; HTN, Hypertension; ICU, Intensive care unit; IQR, Interquartile range; LOS, Length of hospital stay; LVEF, Left ventricular ejection fraction; MRAs, Mineralocorticoid receptor antagonists; NYHA, New York Heart Association; SBP, Systolic blood pressure; SCr, Serum creatinine; SD, Standard deviation; Y12HMC, Yekatit 12 Hospital Medical College.
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0310251#abstract0
