Hannah Billig, Muntadher Al Zaidi, Florian Quacken, Jan Görtzen-Patin, Philip Roger Goody, Ingo Gräff, Georg Nickenig, Sebastian Zimmer, Adem Aksoy
Abstract
Lactate and glucose are widely used biochemical parameters in current predictive risk scores for cardiogenic shock. Data regarding the relationship between lactate and glucose levels in cardiogenic shock are limited.
Introduction
Cardiogenic Shock (CS) is a critical syndrome of systemic hypoperfusion and tissue hypoxia associated with high mortality [1]. In-hospital mortality rates of 40–62% have been reported [2], and therefore, early identification of the underlying cause of CS is crucial.
Material and Methods
We conducted a retrospective, single-center analysis at our tertiary academic center. Patients with cardiogenic shock treated from 2016 to 2018 were included.
Result
Demographic and clinical characteristics of study participants (overall, and stratified by survival) are summarized in Table 1. The analysis of baseline characteristics was exploratory, intended to identify potential patterns or differences that may warrant further investigation.
Discussion
The major findings of this retrospective study are: first, there is a significant non-linear relationship between glucose and lactate at baseline in patients with cardiogenic shock (CS).
Conclusion
In this cohort of critically-ill patients with and without known diabetes, lactate at admission was superior for mortality prediction in comparison to glucose.
Citation: Billig H, Al Zaidi M, Quacken F, Görtzen-Patin J, Goody PR, Gräff I, et al. (2024) Blood glucose and lactate levels as early predictive markers in patients presenting with cardiogenic shock: A retrospective cohort study. PLoS ONE 19(7): e0306107. https://doi.org/10.1371/journal.pone.0306107
Editor: Gaetano Santulli, Albert Einstein College of Medicine, UNITED STATES
Received: January 24, 2024; Accepted: June 11, 2024; Published: July 25, 2024
Copyright: © 2024 Billig et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: Due to the sensitive nature of the medical data involved in this study and the privacy agreements under which the data was collected, the full dataset for this retrospective analysis is not publicly available. The data contains confidential patient information, and its public disclosure is restricted by ethical and legal regulations to protect patient privacy. However, the dataset can be made available upon reasonable request. Requests for access to the data will be reviewed on a case-by-case basis to ensure compliance with applicable privacy laws and institutional policies. Potential recipients will be required to sign a data access agreement that mandates the confidential handling of the data. Data requests may be sent to the Research Data Service Center of the University Bonn (researchdata@uni-bonn.de). The institutional repository guarantees data preservation for at least 10 years post-publication, ensuring long-term accessibility.
Funding: The author(s) received no specific funding for this work.
Competing interests: The authors have declared that no competing interests exist.
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0306107#abstract0
