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Montreal Heart Institute Applauds FDA Approval of Colchicine for Cardiovascular Disease Treatment

Saturday, June 24, 2023

The Montreal Heart Institute (MHI) is pleased to announce its support for the recent approval of colchicine by the United States Food and Drug Administration (FDA) for cardiovascular prevention. This marks a significant milestone as low-dose colchicine (0.5 mg once daily) becomes the first anti-inflammatory medication authorized for reducing the risk of myocardial infarction, stroke, coronary revascularization, and cardiovascular death in adult patients with atherosclerotic coronary artery disease, a condition characterized by artery narrowing caused by deposits.

Two extensive clinical studies, namely COLCOT and LoDoCo-2, have contributed to our understanding of colchicine's effects on cardiovascular health. Inflammation has long been recognized as a contributor to atherosclerosis and an elevated risk of cardiovascular events. Through the COLCOT and LoDoCo-2 studies, we have demonstrated that addressing inflammation can effectively reduce the occurrence of cardiovascular events in patients who have previously experienced a heart attack. The FDA's approval of colchicine signifies a significant advancement in patient care, highlighting the role of inflammation as an underlying cause of atherosclerotic coronary artery disease and heralding a new era of targeted treatment.

In the COLCOT study, which focused on patients who recently suffered a myocardial infarction, low-dose colchicine was compared to a placebo alongside standard treatment. Published in the New England Journal of Medicine, the study revealed that colchicine treatment significantly reduced the risk of new ischemic cardiovascular events by 23% and the risk of total ischemic events by 34% in patients with a history of myocardial infarction.

Conversely, the LoDoCo-2 study targeted patients with stable atherosclerotic cardiovascular disease. The study demonstrated that the addition of colchicine to standard prevention treatments resulted in a 31% reduction in the risk of cardiovascular events.

The Montreal Heart Institute welcomes the FDA's approval of colchicine, recognizing the immense potential it holds for improving patient care. By addressing inflammation as a key factor in atherosclerotic coronary artery disease, we can enhance our ability to manage and prevent cardiovascular diseases. This approval marks a significant step forward in advancing treatment strategies and enhancing patient outcomes.



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