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ClearPoint Neuro Extends Software License and Research Agreement with Philips to Include Fully Automatic Subnuclei Segmentation for DBS

Wednesday, April 12, 2023

ClearPoint Neuro, Inc., a global therapy-enabling platform company providing navigation and delivery to the brain, today announced further expansion of its worldwide license and research agreement with Philips, a global leader in health technology, to add subnuclei segmentation applied to MRI, and potentially CT scans, for use in the operating room. The design goal of the ClearPoint Maestro® Brain Model is to enable highly accurate ClearPoint interventions under both MRI and CT guidance by facilitating patient-specific, multi-modal fusion for accurate target identification and trajectory planning.

“Extending our software collaboration with Philips beyond the subcortical brain regions in Maestro to include segmentation of subnuclei from MRI is key to our planned expansion into the operating room,” commented Joe Burnett, President and CEO of ClearPoint Neuro. “ClearPoint has built our brand based on our unique suite of MRI Guidance hardware and software and with more than 10 years of experience and 6,000 cases, we have learned a lot under challenging conditions. We continue our progression as a platform neuro-navigation company by leveraging what we have learned in the MRI and applying that learning to other surgical arenas in the hospital. This new agreement with Philips will optimize the computational speed of Maestro and enable the fully automatic segmentation of clinically approved deep brain stimulation targets (DBS) including the globus pallidus internus (GPi), the subthalamic nucleus (STN), the ventral intermedius nucleus (VIM), and the anterior nucleus of the thalamus (ANT). DBS targets planned in the space of a pre-op MRI can be mapped to plans in an operating room surgical environment using other interventional modalities like CT. This will allow surgeons to select which patients benefit from CT compared to MRI based on their presentation, but still take advantage of many unique and valuable features of the ClearPoint platform.”

ClearPoint Maestro Brain Model emerged over 10 years ago from research aimed at detecting subtle volumetric and shape abnormalities in patients with mild traumatic brain injury. That first study was featured on the cover of the Journal of Neurotrauma. The unique methodology of the brain model combines deformable surfaces with active shape models and machine learning. More importantly, it provides point-based correspondence longitudinally and across patients. Cross-validation on more than 1,000 scans demonstrated highly reproducible results with sub-millimeter accuracy and normative values from 560 healthy subjects provided reference ranges for patient-specific assessments. Maestro was FDA cleared in 2022 and is currently in limited market release at select U.S. academic medical centers and in pharmaceutical clinical trials.



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